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Results: MTX altered the concentration of 31 out of 70 metabolites analyzed, suggesting inhibition of the glycine cleavage system, the pentose phosphate pathway, purine and pyrimidine synthesis, phospholipid metabolism, and bile acid uptake
Funding This study was supported by the Outstanding Talent Pool Key Support Object Projects of Army Medical University (Number: XZ-2019-505-021) and the Project of Military Key Clinical Specialty (Number: 51561Z23711)
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Most patients notice deeper sleep within the first 1 to 2 weeks, faster recovery by weeks 3 to 4, body composition changes by weeks 5 to 8, and skin and energy improvements by weeks 8 to 12
The reduction of GSSG is catalyzed by GSH reductase (GR), utilizing NADPH in the process
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