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It resists dramatic changes in hormone levels from dietary inputs, which is actually a protective feature, not a limitation to overcome

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The first human safety study on health volunteers was conducted in 2002 and a phase 2 double blind, randomized clinical trial (small and not sufficient for US phase 2 purposes) was conducted in 2005 with BPC-157 enemas for ulcerative colitis, with some promising effects (see research name PL 14736 to find the references)

Its uncommon, but possible if youre not eating enough or losing weight very rapidly

That compares with Novo Nordisk, which launched its Wegovy weight loss pill in January and saw 600,000 prescriptions in its first two months