In this guide, well break down how sermorelin and ipamorelin work, what sets them apart, and how to choose the right one based on your goals
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Brand reputation: Choose products from providers that can guarantee third-party testing, proper formulation standards, and clinical support
A 2026 clinical commentary in Functional Medicine noted that unstructured caloric restriction during GLP-1 therapy, particularly when it trends toward processed or nutrient-poor foods, can reduce the substrates needed to support beneficial bacteria like Bifidobacterium, Akkermansia muciniphila, and Lactobacillus species
Increase hunger: Peptides like CJC-1295, Ipamorelin, or Tesamorelin stimulate the release of growth hormones, which can temporarily increase appetite during the first few weeks of use