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615 Furthermore, the transfer of vitrified spindles into fresh cytoplasm led to the birth of four healthy rhesus monkey infants, with no significant changes in mtDNA heterogeneity
The Ecuadorian Laron and Brazilian Itabaianinha cohorts with congenital mutations in the GH and GHRH receptors, respectively, both provide a unique and arguably the purest examples to evaluate the effects of chronic severe IGF-I and both severe GH and IGF-I deficiency, respectively, with severe hypoinsulinemia being the common denominator in both cohorts (151, 152) ( Table 1
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