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Tolerability and Safety Questions Both candidates are likely to be judged partly on gastrointestinal tolerability: nausea, vomiting, diarrhea, constipation, dose escalation, and discontinuation due to adverse events

GLP-1MK-801 produced a vehicle-corrected reduction in body fat mass of 45%, accompanied by an 8% loss in lean mass (Fig

Cancer stem cells (CSCs), characterized by self-renewal, differentiation potential, and resistance to chemotherapy and radiotherapy, contribute significantly to tumor progression [9,10,11,12]