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Tirzepatide has shown similar results: in a phase 2 trial, up to 73.3% of participants at the highest dose achieved MASH resolution without worsening fibrosis at 52 weeks, compared to 13.2% on placebo
In principle, a similar approach could be trialled with other fluorescent markers that accumulate in different subcellular compartments
Biochem Biophys Res Commun (2010) 400(4):72933.10.1016/j.bbrc.2010.08.138 42 BernsenPLGabrelsFJRuitenbeekWHamburgerHL
Mounjaro is the brand name for tirzepatide, a once-a-week injection
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