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Clinicians began exploring this approach for a few reasons: Not everyone needs aggressive appetite suppression to improve metabolic health Some people are more sensitive to GLP-1 medications Side effects often increase with higher doses Cost and long-term sustainability matter Women, in particular, started asking different questions
However, SGLT2 inhibitors cause substantially less weight loss than expected from the energy excreted via glycosuria, because it elicits an adaptive increase in energy intake, including compensatory increases in appetite/caloric intake [40]
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Heres a detailed look at their performance in weight reduction: Weight loss achievements: Zepbound: Clinical trials have shown impressive weight loss results with Zepbound
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