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Notably, Piezo1 channel function inhibition slows myopia progression and partially reduces retinal ROS levels in FDM guinea pigs
Some institutions now recommend withholding GLP-1RAs for 12 weeks before elective procedures, particularly if the patient is early in treatment or shows symptoms of gastroparesis
Circulation 2008;117:23402350
Tirzepatide, another GLP-1 option, was not included because it became available after the study began
The appetite-suppressive effects create a secondary concern: patients taking both drugs may inadvertently restrict calories to unsafe levels, leading to nutrient deficiencies, muscle loss, or metabolic adaptation that undermines long-term weight loss
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