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It is also possible that mutation of S2 site residues could alter indirectly a putative cryptic binding site at the oligomeric interface especially as these mutants affect oligomerisation in our cell-based assays (Supplementary Fig

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The thyroid gland will try to overcompensate and produce more thyroid hormones (T3 and T4) to keep the levels normal even as the gland and the hormones themselves are being destroyed

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