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Activation of genes encoding antioxidant enzymes such as catalases and GST1 was detected in the tissue surrounding the initial infection site (Schenk et al., 2000)
doi: 10.1016/J.PHRS.2017.11.027 344 LinJCookNRAlbertCZaharrisEGazianoJMVan DenburghMet al
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First, ROS directly modifies ion channels, oxidizing sulfhydryl groups on voltage-gated Na+ channels, resulting in abnormal action potential propagation and contributing to the paradoxical coexistence of pain and numbness (Elafros et al., 2022)
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