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Bupropion activates neurons in the hypothalamus that reduce appetite, while naltrexone blocks the brains counter-signal that would normally shut that appetite suppression off
Independently tested
A 2025 pilot study tested IV BPC-157 up to 20 mg in 2 healthy adults for safety only, finding it well tolerated but conducting no efficacy testing
Unreacted sites were capped with ethanolamine (1.0 M ethanolamine in 10 mM PBS, pH 8.1, 7 min)
Lack of Human Trials One of the major safety limitations of BPC-157 is the absence of large-scale, peer-reviewed human trials
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