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Dosis tpicas: Las dosis en estudios varan entre 500 mg y 3 gramos diarios, divididas en 2 o 3 tomas para mejorar la absorcin y tolerancia
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Additionally, glutamine deprivation or GLS1 inhibition represses glycolysis and lactate production in several cancer cells through upregulation of thioredoxin interacting protein (TXNIP) and phosphorylation of PFKFB3, potentially reducing lactate-induced differentiation of M2 macrophages (94, 95)
Idebenone also exerted a certain inhibitory effect on cyst growth
However, despite being the mainstay of CRC chemotherapy treatment, the primary anti-tumour mechanismsand more importantly, mechanisms facilitating 5FU resistance and persistenceremain poorly defined
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