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Platinum drugs (e.g., RMA19 and RMA35) are also irreversible inhibitors of mammalian TrxR [31,32]

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Other drugs found to inhibit vitamin B 12 absorption from food include cholestyramine (a bile acid-binding resin used in the treatment of high cholesterol), chloramphenicol and neomycin (antibiotics), and colchicine (medicine for gout treatment)

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These factors motivate transcriptomic and proteomic profiling to detect unanticipated pathway activation, coupled with dose-window optimization to balance metabolic efficacy with system-level perturbations

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