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In addition, the FDA also must ensure the integrity of the drug approval process and, thus, does not permit 503B compounders to market versions of compounded products that are essentially duplicate copies of approved drug products unless there is a documented patient-specific need for an alternate form of the compounded product

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Two randomized control clinical trials reported conflicting effects on bone mineral content (BMC) and bone mineral density (BMD): one trial demonstrated preservation of BMC with GLP-1 use, while the other found no significant difference in BMC or BMD between treatment and control groups

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