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The side-chain guanidyl group of Arg454 interacts with the carboxylate moiety of glycine to orient the substrate for attack on the acyl-phosphate intermediate (Herrera et al., Unlike other organisms, some plants synthesize glutathione analogs in which -alanine, serine, or glutamate replaces glycine in the tripeptide (Figure 4A)
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"Comparative Effectiveness of Dual-Agonist Obesity Therapeutics: A Systematic Review and Meta-Analysis." The Lancet Diabetes & Endocrinology, 2024, 12(2): 123-138
Glutathione l mt cht c nhiu tc dng i vi sc khe nh: chng oxy ha, lm trng da, thi c gan, tng cng h min dch, h tr tim mch
