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In July 2009, they published a paper in Nature Chemical Biology, reporting for the first time that dual agonists targeting GLP-1R and glucagon receptor (GCGR) had a better weight loss effect

The absence of VPAC2 leads to aberrant antibody production in aspergillus fumigatus sensitized and challenged mice

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Basu, K

This deleterious effect could depend on a shift in proteasome composition from classical to immunoproteasome subunits, a phenomenon known to play a role in the neurotoxicity observed in neurodegenerative diseases, and on an increase in chymotrypsin-like and trypsin-like activities (Pla et al., 2014)