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LY3437943 (Retatrutide): discovery to clinical proof of concept (triple GLP-1/GIP/glucagon agonist, preclinical mechanism) Nature Reviews Endocrinology (2024) Multi-receptor agonists for metabolic disease (mechanism of GLP-1/GIP/glucagon co-activation) Diabetes Care (2024) Incretin-based therapies: GLP-1, GIP, and glucagon receptor pharmacology (metabolic pathways, energy expenditure) NEJM (2023) Supplementary Material Jastreboff et al
Peptides address biochemical repair
When you inject something, what's in the vial matters more than what's on the label
BPC-157 was first isolated from body protection compound (BPC), which is found in the gastric juices and is part of the digestive process [1]
Over the following decades, it became widely used in Europe and Asia
