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Discussion In this study, a systematic review was first conducted as a hypothesis-driven approach to objectively evaluate the main pathological changes during OA development and identify potential therapeutic targets

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However, the combination of GLP-1 receptor agonists with DPP-4 inhibitors have not demonstrated clinically significant additional benefits [116]

Semaglutide, the active ingredient in Ozempic and Wegovy, is composed of 31 amino acids with a C18 fatty acid modification attached via a linker to a specific lysine residue

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