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In such outcome trials of DPP-4 inhibitors, SGLT2 inhibitors, and GLP-1 RAs, the study drug is compared with placebo, with both agents given in addition to standard care
Tirzepatide is particularly suitable for adults in San Francisco who are overweight or obese and haven't seen the desired results from traditional methods
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The SURPASS-CVOT trial, where dulaglutide at the dose of 1.5 mg/week or at the highest tolerated dose, is the comparator, has a distinctive design from the other trials: the primary endpoint is the time to the first manifestation of any major adverse CV event (MACE), defined as myocardial infarction, stroke or CV death
Avoid ibuprofen if you are experiencing vomiting, diarrhoea, or dehydration whilst on Rybelsus, as this combination increases kidney problem risk
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