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In 1978, building on this discovery, Zamecnik and Stephenson 32 used specific oligodeoxynucleotide chains that target the 35S RNA of the Rous sarcoma virus to inhibit virus replication, marking a prototype for the application of antisense oligonucleotide (ASO) drugs in disease treatment
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The expression levels of seleno-GPxs can be increased either through transcriptional induction or by elevating bioavailable selenium which supports their translation [8, 20, 24,25,26,27]
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