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Additionally, patients initiating treatment with semaglutide 1 mg may have received higher doses of their baseline GLP-1 RA, meaning that the improvements brought by switching to semaglutide were comparatively less pronounced in these patients

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Large-scale clinical trials have demonstrated that GLP-1RAs predominantly exhibit neutral or suppressive effects on overall cancer risk, with semaglutide showing no elevated cancer incidence [14], while significant reductions have been observed in specific malignancies, particularly liver cancers and prostate cancers [13, 15]

Its role is to stimulate the production of insulin, therefore allowing glucose to enter cells and lowering blood sugar levels