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Following chronic (6 week) feeding with an ethanol-containing liquid diet, the Gclm KO mice were unexpectedly found to be protected against steatosis despite showing increased oxidative stress (as reflected in elevated levels of CYP2E1 and protein carbonyls)
When performing an intention-to-treat analysis, the HR for MOF was found to be 0.89 [0.781.02] with GLP-1 RAs compared to DPP-4is, although this became significant in the fully adjusted model (HR 0.85 [0.74 0.98])
Gupta S, Dey YN, Kannojia P, Halder AK, Sharma D, Wanjari MM, et al
1): (A) Placebo condition: oral placebo followed by smoked or vaporized placebo
p=0.04)
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