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A reaction that depletes cellular NAD+ pools and methyl donor availability
Come prepared to share your medical history, current medications and health conditions, and goals for weight loss or type 2 diabetes
Let your provider know about any unexpected effects, severe side effects, or concerns
Cyanocobalamin (vitamin B12) is sometimes added because it can reduce injection-site discomfort for some patients and may support those who are B12-deficient
Current Evidence and Clinical Trial Findings Phase 2 data published in the NEJM (2023) showed dose-dependent body weight reductions with retatrutide over 48 weeks, with gastrointestinal side effects being the most commonly reported
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