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However, this inhibitory effect is significantly weakened in patients with T2DM, indicating that its potential application in diabetes treatment requires further investigation.241 Through this series of complex molecular and cellular mechanisms, GLP-1 plays a vital role in the physiological and pathological processes of metabolic diseases like T2DM.232,233,241,259 (Fig

In situ cell-type-specific cell-surface proteomic profiling in mice

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These medications are FDA-approved for the treatment of obesity, a chronic disease usually characterized by a BMI of 30 or higher