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Rinaman said, It could be that were underestimating the amount to which these drugs penetrate just by virtue of the way those experiments are done and the non-enhanced visualization of the receptors. There are various reasons that the experiments using the fluorescent tags may underestimate the extent to which the GLP-1R agonists reach targets in the brain, she added

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Over time, that can turn mild GLP-1 tiredness into something that feels constant