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Unlike MT-1 10mg (Afamelanotide), which is selective for MC1R, MT-2 is a non-selective melanocortin agonist activating four receptor subtypes simultaneously: MC1R (melanocytes, pigmentation research), MC3R (immune modulation and energy balance research), MC4R (energy homeostasis and appetite regulation research), and MC5R (exocrine gland secretion research)
The medication does not act as an inducer or inhibitor of major CYP enzymes
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10.1016/S0140-6736(23)00020-X 24 ChenG.NiculaD.RenkoK.DerwahlM
Intranasal leptin induces significant weight loss and reduction of adipose tissue mass in lean and diet-induced obesity rats, which is consistent with the results of central leptin administration (Schulz et al., 2012)
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