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Mechanistically, OPA1 and SNX9 promote MDVs' trafficking mitochondrial proteins into EVs, whereas Parkin redirects damaged mitochondrial content toward lysosomal disposal, collectively shaping whether mitochondrial signals are immunologically silent or inflammation enhancing (126)

doi: 10.3390/nu13062113 205 ODriscollM.Ribeiro Dos SantosG.WangL.CummingsD

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Key questions remain unanswered in ARD patients, particularly whether disease-specific factors (altered inflammation, gut microbiome) or ARD treatments (e.g., glucocorticoids, TNF or IL-6 inhibitors) may modify the immunomodulatory effects of GLP-1RAs