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Also sustaining this hypothesis, other authors observed that modulation of IGF-1R-associated genes promoted regulatory clustering as well as stemness and chemoresistance in cells from colorectal cancer patients and mouse models, and was facilitated by a master transcriptional regulator responsive to ribosomal dysfunction, PR domain zinc finger protein 1 (PRDM1) (49)
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This leads us to why these concerns might not translate to human risk
So Im not surprised that close to 100% of my new patients come to me with gut issues and leaky gut, and yes, Ulcerative colitis, too
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