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Patients switching from tirzepatide to orforglipron gained an average of 2.6 kg, compared to 9.1 kg with placebo at 24 weeks

A Mercer 2026 strategy survey found 77% of large employers rated managing GLP-1 costs as "extremely or very important" ( [25] )

Typically, the 1.7 mg and 2.4 mg doses are considered to be maintenance doses, though occasionally patients do perfectly well on the lower doses too

Common complaints The negative reviews reveal some concerning patterns worth understanding before you commit

Product legitimacy Ask whether the product is approved, compounded, investigational, or labeled for research use only