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In another analysis of five randomized controlled trials involving over 700 subjects with venous ulcers, treatment with the diosmin preparation combined with conventional therapy increased the chances of ulcer healing by 32% at six months compared with conventional therapy alone (Coleridge-Smith 2005)
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[13] [15] There is a risk of oxalate nephropathy or kidney stone formation, particularly in patients with pre-existing renal impairment or those receiving prolonged high-dose therapy
Additionally, B12 deficiency affects the nervous system's ability to function optimally
