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Additionally, sulforaphane increased NRF2 target gene expression and enhanced activity of antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR)

This process limits the amount of glutathione that actually makes it into your system, often reducing its effectiveness

This is not a one-or-the-other exposure

Due to its low bioavailability, NAC must be administered at high doses, which can disrupt hepatocyte metabolism and regenerative processes, increase the risk of adverse reactions (Ntamo et al

Collectively, oxidative stress, mitochondrial dysfunction, and glutamate excitotoxicity are causing each other forming a neurotoxic vicious cycle (80)