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Smaller 5 mg format suited to pilot studies, method development, or single-project workflows where smaller quantities are preferred

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Dispersion parameters were estimated, and a design matrix incorporating age, sex, and APOE genotype as covariates was constructed

Reported preclinical doses (for documentary purposes only) vary by route: intranasal (high bioavailability, direct BBB crossing via olfactory and trigeminal pathways), intraperitoneal, subcutaneous

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