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Both tirzepatide and retatrutide produce gastrointestinal side effects as their primary adverse reactions, but the frequency, severity, and specific patterns differ between the two compounds

Melanotic macules are the most common oral mucosal lesions that originate from melanocytes

Cell 2015;160:829-41.ArticlePubMedPMC 48

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This stepwise approach allows the digestive system to adapt progressively, minimising the severity of gastrointestinal symptoms