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These symptoms are usually most pronounced 13 days after injection and typically diminish significantly after 48 weeks as tolerance develops

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Also, metabolites of VPA -oxidation (including propionic derivatives and 4-en-VPA) inhibit the mitochondrial CPS I, which is the first enzyme necessary for ammonia elimination via the urea cycle in the liver [19, 24]

Glucagon-receptor: Bestudeerd vanwege de invloed op het energieverbruik van het lichaam