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Mechanism of Action: Dihexa binds with high affinity to hepatocyte growth factor (HGF), activating c-Met receptors, which leads to increased synaptic connectivity and neurogenesis

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418 Rechallenge strategies, by contrast, operate under the premise of clonal evolution reversibility, whereby reintroducing previously used agents, often after a drug holiday, can resensitize tumors due to regrowth of drug-sensitive clones

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