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Muscles feel less sore, and mood may become more balanced
The weight effect runs through several parallel mechanisms: it activates satiety centers in the hypothalamus so patients feel full sooner and stay full longer, it slows gastric emptying, it modulates reward pathways so calorie-dense foods feel less compelling, and it stabilizes post-meal glucose and insulin
They work by mimicking the action of the naturally occurring GLP-1 hormone, which is released from the intestine in response to food intake
The most likely explanation for cold sensitivity relates to the metabolic changes associated with significant weight loss rather than a direct pharmacological effect of tirzepatide itself
Study approval
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