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The result is not just reduced desire but potentially reduced physical responsiveness, a slower arousal process, and difficulty reaching climax even when desire is present

relative abundance of specific proteins at baseline and week 68 in STEP 1 (a) and STEP 2 (b)

Robert Kushner, a professor of medicine at Northwestern University Feinberg School of Medicine and co-investigator on the STEP trials, has noted: "These medications represent a significant advance, but they work best when paired with lifestyle modification and ongoing clinical support." This perspective is echoed in the 2024 Endocrine Society guideline, which states that "pharmacotherapy for obesity should be used as an adjunct to lifestyle intervention, not as a replacement" [3]

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