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Foundational Characterisation The synthesis and initial characterisation of Melanotan 1 by Hadley and Dorr at the University of Arizona established it as a potent, stable MC1R agonist with substantially enhanced in vivo bioactivity compared to native -MSH, and confirmed its capacity to stimulate melanogenesis in pre-clinical models
Our current study showed that bone graft healing was more efficient in AR flox/Y but not AR -/Y host mice regardless of implanting with either AR flox/Y or AR -/Y ;Prrx1::Cre donor bone, suggesting that AR may orchestrate crucial healing signaling for activation and differentiation of periosteal progenitors in host mice and elimination of AR in periosteum of host mice at the early stage of fracture healing could lead to detrimental effects on periosteum-initiated cortical bone repair
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