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Melanotan-1 (afamelanotide) is a selective MC1R agonist producing melanogenesis with minimal off-target effects, while Melanotan-2 binds MC1R, MC3R, and MC4R causing appetite suppression, spontaneous erections, and nausea at higher rates

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With the unclamping, the tissue reperfusion occurs, determining the brusque arreval of oxygen and nutriens to the tissue, with a meaninful encrease of free radicals, extreme important phenomenon, mainly during the first 60 to 90 seconds, because it damages the reperfused area, provoking micro-heart attacks (Haliwell and Gutteridge, 1989)

10.1016/j.vph.2015.08.012 16 ChenX.DingC.LiuW.LiuX.ZhaoY.ZhengY.et al (2021)