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Similarly to SOD1 and SOD2, also SOD3 is involved in the detoxification of ROS by the catalytic dismutation of superoxide radical anion

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The pathophysiology of endothelial dysfunction is complex, in that it is based on endothelial nitric oxide synthase uncoupling and endothelial activation following stimulation by various inflammatory mediators (molecular patterns, oxidized lipoproteins, and cytokines) (46)

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