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Leptin is a hormone that fat tissue produces
While B12 is generally safe, caution is needed in specific clinical situations: Lebers Disease (Hereditary Optic Neuropathy): B12 injections are generally contraindicated or should be used with extreme caution, as they may potentially aggravate optic atrophy in this rare condition
Stratified by baseline weight or BMI Subgroup analyses were performed bounded by the weighted median of baseline weight (105.6 kg)
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