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To view a copy of this license, visit About this article Cite this article Heldring, M.M., Shaw, A.H

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

Researchers have investigated whether dual activation of GIP and GLP-1 receptors produces effects that differ from single-agonist research compounds, particularly in the context of preclinical models of metabolic dysfunction