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In hypertension, GLP-1 attenuates the excitability of carotid body cells diminishing sympathetic activation, augments renal blood flow to promote natriuresis and diuresis as well as facilitates generation of nitric oxide in vascular smooth muscle cells

Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J, Arnold M, Erte I, Forgetta V, Yang TP, et al

The problem prescription GLP-1 medications like Ozempic and Wegovy solve is mimicking GLP-1 so that the medication acts in the body for a much longer period of time

42 The effects of GLP-1 RAs in HFrEF have been studied in several small trials

For example, the abdomen, thigh, or upper arm