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The endocrine and metabolic adaptation observed in both models may be a strategy to increase life span through a slower cell growing/metabolism, a slower loss of physiologic reserve capacity, a shift of cellular metabolism from cell proliferation to repair activities and a decrease in accumulation of senescent cells
We determined the GTP-binding protein coupling of human GCGR expressed in HEK293T cells
The mechanism of action involves simultaneous activation of both GIP and GLP-1 receptors, which are naturally produced in the gastrointestinal tract
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doi: 10.1186/s40104-018-0298-1 7 AlkhashabA
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