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If the off-label use of GLP-1s for type 1 diabetes becomes so prevalent as to be impossible to ignore, the FDA might mandate the companies to go and do these studies, says Garg

Choosing between GLP-1s and deciding how dosing should be approached is not something most people should guess at

Krumholz explains

However, overlap exists in downstream effects on glucose and lipid metabolism, meaning additive effects are possible but not guaranteed for every person