The NHS prescription charge applies (9.65 per item in England as of 2023/24, though prescriptions are free in Scotland, Wales, and Northern Ireland), but patients with diabetes or certain other conditions may be exempt
Most patients find that side effects become manageable by week 23 of each dose level and resolve entirely once they reach their maintenance dose
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However, a recent systematic review carried out in 2017 revealed that euthyroid iodine-repleted subjects exposed to soy isoflavonoids have a slight TSH increase with no changes in FT3 and FT4 levels [162]