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The speed at which tirzepatide works surprises many users, with appetite changes often noticeable within the first week or two of treatment
However, reduced overall food intake may inadvertently decrease magnesium consumption, particularly if patients limit magnesium-rich foods such as green leafy vegetables, nuts, seeds, whole grains, and legumes
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In addition to this endocrine action, the local inhibitory effect of DPP-4 inhibitors on GLP-1 degradation in the intestinal mucosa may contribute to favorable metabolic regulation by stimulating the autonomic afferent nervous system (10, 19)