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Abbreviations PCOS: Polycystic ovary syndrome POI: Premature ovarian insufficiency GPX4: Glutathione peroxidase 4 GSH: Glutathione LPCAT3: Lysophosphatidylcholine acyltransferase 3 NCOA4: Nuclear receptor coactivator 4 ACSL4: Acyl-CoA synthetase long-chain family member 4 TfR1: Transferrin receptor 1 FPN: Ferroportin PUFAs: Polyunsaturated fatty acids ROS: Reactive oxygen species ALOX15: Arachidonate 15-lipoxygenase LOX: Lipoxygenase LIP: Labile iron pool IREB2: Iron-responsive element-binding protein 2 Tf: Transferrin FTH1: Ferritin heavy chain 1 FSH: Follicle-stimulating hormone LH: Luteinizing hormone NCOA4: Nuclear receptor coactivator 4 FSP1: Ferroptosis suppressor protein 1 ACSL4: Acyl-CoA synthetase long-chain family member 4 SCD1: Stearoyl-CoA desaturase 1 CD44: Cluster of differentiation 44 HO-1: Heme oxygenase-1 NRF2: Nuclear factor erythroid 2-related factor 2 References Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascn S, Hatzios SK, Kagan VE et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease

The red blood cells are enlarged because of abnormal DNA synthesis in red blood cell precursors, which results in abnormal erythrocyte development (Khanduri 2007)

The 8-12 week mark is the first major milestone

Taken together, the results corroborated that GSH inhibited PSC activation via down-regulation of the TGF-/SMAD pathway

The GLP-1 component handles appetite suppression and insulin regulation, similar to what semaglutide does alone