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Critically, the excessive buildup of iron within the brain establishes a self-sustaining cycle: iron accumulation promotes -amyloid (A) aggregation and tau hyperphosphorylation (Tran et al., 2022), while A plaques in turn sequester iron via their metal-binding domains, increasing local Fenton reaction activity (Tang et al., 2024)

The Dual Agonist: Tirzepatide Tirzepatide targets two distinct nutrient-stimulated hormone pathways: GLP-1 (Glucagon-Like Peptide-1): Activates receptors in the brain to delay gastric emptying, induce early satiety, and reduce central appetite signals

They are found in foods such as meats, fish, and soybeans