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Medical experts now believe that using non-oral estrogen (usually an estradiol patch) minimizes the risk of blood clots, although more research is needed, Santoro said
Baseline: Metformin 1000-2000mg daily, stable dose Weeks 1-4: Add Retatrutide 1mg weekly, maintain Metformin Weeks 5-8: Increase Retatrutide to 4mg weekly Weeks 9-12: Increase Retatrutide to 8mg weekly Week 12+: Assess A1C and consider Retatrutide dose increase to 12mg if needed
Community-derived cycle structures most often run 4-6 weeks on followed by 2-4 weeks off
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For researchers on higher doses, 1-2 units is negligible
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